TABLE 1.

Gross pathological observations of mice passively immunized or opsonized with P. gingivalis-specific IgG and challenged with P. gingivalis in a murine subcutaneous chamber model^a

Group	Expt parameter			Result
	Passive transfer	Opsonization	Challenge with	Lesionsb	Cachexiac
1	None	None	None	None (0/8)	None
2	None	None	P. gingivalis A7436	++++ (2/8)	Moderate
3	P. gingivalis-specific IgG	None	P. gingivalis A7436	None (0/8)	None
4	IRR-IgG	None	P. gingivalis A7436	++++ (4/8)	Severe
5	None	P. gingivalis-specific IgG	P. gingivalis A7436	None (0/8)	None
6	None	IRR-IgG	P. gingivalis A7436	++++ (3/8)	Severe

^aGroups of animals received vehicle only (none), 100 μg of murine P. gingivalis-specific IgG, or 100 μg of IRR-IgG 24 h prior to chamber challenge or were challenged with P. gingivalis opsonized with 100 μg of either P. gingivalis-specific IgG or IRR-IgG.

^bThe severity of the lesions was determined by using an arbitrary four-plus scale whereby lesions spreading from the area of challenge are considered the most severe. After 10 days, mice were observed for evidence of chamber rejection, and the number in parentheses is the number of mice with chamber rejection.

^cCachexia was expressed as none, moderate, or severe and was determined as a function of animal hunching, ruffled hair, and lethargy.