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Memantine IC50, amantadine IC50, and ΔΔG° for wild-type and mutant NMDA receptors containing mutations in GluN1. (a) Effect of introducing Asn mutations at select sites. (b) Aliphatic mutations at residue N1-645. The values for IC50 ± SEM are shown in Table 1. ΔΔG° values are shown above the corresponding columns.
