Table 3.
Antiviral activities of ethanol extracts of T. sureni leaves (TSL), M. latifolia leaves (MLL), M. multiglandulosa stem (MMS) and F.fistulosa leaves (FFL) against various HCV strains of different genotypes
| HCV strain (genotype) |
% Inhibitiona |
|||
|---|---|---|---|---|
|
T. sureni leaves |
M. latifolia leaves |
M. multiglandulosa stem |
F. fistulosa leaves |
|
| (TSL) | (MLL) | (MMS) | (FFL) | |
| J6/JFH1 P47 (2a) |
97.2 ± 1.3b |
98.0 ± 0.3 |
86.7 ± 1.4 |
93.8 ± 1.3 |
| J6/JFH1 (2a) |
98.5 ± 2.1 |
99.5 ± 0.7 |
73.2 ± 2.1 |
96.1 ± 1.4 |
| JFH1 (2a) |
100 ± 0.0 |
100.0 ± 0.0 |
67.3 ± 8.2 |
92.3 ± 0.0 |
| H77C/JFH1 (1a) |
98.2 ± 2.5 |
100.0 ± 0.0 |
83.9 ± 2.5 |
5.4 ± 2.5c |
| J4/JFH1 (1b) |
79.2 ± 11.8 |
91.7 ± 5.9 |
72.9 ± 8.8 |
93.8 ± 2.9 |
| J8/JFH1 (2b) |
100.0 ± 0.0 |
100.0 ± 0.0 |
34.4 ± 13.3c |
93.8 ± 0.0 |
| S52/JFH1 (3a) |
97.8 ± 3.1 |
100.0 ± 0.0 |
95.6 ± 3.1 |
97.8 ± 0.0 |
| ED43/JFH1 (4a) |
94.2 ± 1.2 |
98.3 ± 0.0 |
59.5 ± 1.2 |
97.5 ± 1.2 |
| SA13/JFH1 (5a) |
100.0 ± 0.0 |
96.1 ± 1.1 |
89.8 ± 1.1 |
93.8 ± 2.2 |
| HK6a/JFH1 (6a) |
100.0 ± 0.0 |
91.2 ± 4.2 |
67.6 ± 20.8 |
91.2 ± 4.2 |
| QC69/JFH1 (7a) | 100.0 ± 0.0 | 87.0 ± 6.1 | 39.1 ± 0.0c | 95.7 ± 6.1 |
a% Inhibition at the concentration of 30 μg/ml.
bData represent means ± SEM of data from two independent experiments using HCV J6/JFH1-P47.
c% Inhibition of <40% are written in boldface letters.