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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Science. 2013 Feb 1;339(6119):584–587. doi: 10.1126/science.1231456

Fig. 1. Quantitative analysis of single-cell stochastic gene regulation.

Fig. 1

A) Schematic of a generic signaling cascade in which a kinase enters the nucleus and interacts with transcription factors (TF) and chromatin modifiers (CM) to regulate gene expression. B) Rapid, stochastic and bimodal activation of endogenous STL1 mRNA expression is detected with single-molecule RNA-FISH (yeast cell: grey circle, DAPI stained nucleus: blue, STL1 mRNA: green dots, scale bar: 2 µm).