FIG. 2.
Parasite loads and lesion sizes during infection. (A) Parasite loads in the footpads of TLR4-competent and TLR4-deficient mice during the course of L. major infection. Groups of wild-type (filled circles) and TLR40/0 (open circles) mice were infected with 2 × 106 L. major promastigotes. At 5, 28, and 78 days postinfection, the numbers of viable parasites in the infected footpads were determined by a limiting dilution assay. Each symbol represents one mouse, and the horizontal black bars represent the means for four individual mice. *, P < 0.05. N.D., not detectable. (B) Lesion sizes in TLR4-competent and TLR4-deficient mice during L. major infection. Groups of wild-type (n = 4; filled circles) and TLR40/0 (n = 4; open circles) mice were infected with 2 × 106 L. major promastigotes. Values represent the lesion sizes of individual mice at the indicated times after infection. Each symbol represents one mouse, and the horizontal black bars represent the means for four individual mice. *, P < 0.05.