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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Chem Rev. 2013 Feb 26;113(4):2343–2394. doi: 10.1021/cr3003533

Table 2.

Mass analyzers used in shotgun proteomics and their commonly-achieved analytical metrics for peptide analysis.

Analyzer Instruments Type Resolution Mass accuracy Dynamic Range
Quadrupole QQQ
QToF		 Beam 1 – 2 K ~ 1 ‰a 5 – 6
Ion trap LIT Trapping (Electric field) 1 – 2 K ~ 1 ‰a 3 – 4
ToF QToF Beam 10 – 50 K 5 – 10 ppm 4
Orbitrap FT Trapping (Electric field) 7.5 – 240 K 500 ppb – 10 ppm 4
ICR FT Trapping (Magnetic and axial DC fields) 100 – 500 K ~100 ppb 3
a

parts-per-thousand.