Table 3.
Clinicopathological features of the 389 patients with primary breast carcinomas according to methylation status of NDRG1
|
Clinical |
Samples |
NDRG1 |
|
|
|---|---|---|---|---|
| Data | n | M | ORs (95%CIs) | P value |
| Menopausal status |
|
|
|
|
| Pre- |
162 |
51 |
1.0 |
|
| Post- |
227 |
70 |
1.86(0.84-4.14) |
0.126 |
| Tumor size |
|
|
|
|
| <1.0 |
7 |
3 |
1.0 |
|
| 1.0-1.9 |
136 |
45 |
0.84(0.14-4.88) |
0.842 |
| 2-3 |
200 |
61 |
0.64(0.11-3.69) |
0.615 |
| ≥3.1 |
46 |
12 |
0.55(0.08-3.59) |
0.535 |
| Histological grade |
|
|
|
|
| Well |
150 |
35 |
1.0 |
|
| Moderate |
207 |
72 |
1.89(1.20-3.20) |
0.017 |
| Poor |
32 |
14 |
2.96(1.19-7.39) |
0.020 |
| Metastasis |
|
|
|
|
| Negative |
232 |
63 |
1.0 |
|
| Positive |
157 |
58 |
1.94(1.10-3.40) |
0.021 |
| Lymph node invasion |
|
|
|
|
| Negative |
86 |
20 |
1.0 |
|
| Positive |
303 |
101 |
2.22(1.19-4.11) |
0.011 |
| TNM stage |
|
|
|
|
| 0/I |
87 |
20 |
1.0 |
|
| II |
173 |
53 |
1.88(0.96-3.67) |
0.064 |
| III/IV |
129 |
48 |
2.82(1.41-5.62) |
0.003 |
| p53 mutation |
|
|
|
|
| Wild |
160 |
50 |
1.0 |
|
| Mutant |
229 |
71 |
1.04(0.64-1.70) |
0.865 |
| HER2 status |
|
|
|
|
| Negative |
270 |
86 |
1.0 |
|
| Positive |
119 |
35 |
0.83(0.49-1.39) |
0.472 |
| Ki67 proliferation index |
|
|
|
|
| <10% |
93 |
32 |
1.0 |
|
| 10%-32% |
152 |
44 |
0.66(0.35-1.25) |
0.200 |
| ≧33% | 144 | 45 | 0.78(0.41-1.48) | 0.441 |