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H4K5Ac binding occurs at the TSSs of genes. The figure shows the distribution of H4K5Ac binding in (A) control rats (SS), (B) METH-naïve rats treated with an acute injection of METH (SM), (C) rats chronically exposed to METH and then treated acutely with saline (MS), and (D) rats chronically exposed to METH and then given an acute injection of METH before being euthanized (MM). The pattern of H4K5Ac binding in the brain was not influenced by neither acute nor chronic METH exposure.
