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ChIP-Seq analysis shows that methamphetamine caused large-scale increased H4K5Ac binding in the rat striatum. The Venn diagram in (A) shows the overlap of the effects of acute and chronic METH administration on H4K5Ac binding in the four experimental groups: SS, SM, MS, and MM groups. The Venn diagram in (B) shows additional H4K5Ac binding sites in the groups treated with METH in comparison with the control (SS) group.
