Table 3.
Effect of GF109203X (GF) on visceromotor response to phasic ascending colorectal distention over time following exposure to single-prolonged stress (SPS)
| Group | 10 mm Hg | 20 mm Hg | 40 mm Hg | 60 mm Hg |
|---|---|---|---|---|
| Control (n = 8) |
0.055 ± 0.006 |
0.259 ± 0.013 |
0.380 ± 0.014$ |
0.535 ± 0.020$ |
| SPS + Vehicle (n = 7) |
0.059 ± 0.007 |
0.299 ± 0.013 |
0.670 ± 0.028# |
0.896 ± 0.008# |
| SPS + GF (0.05 nmol) (n = 7) |
0.059 ± 0.004 |
0.293 ± 0.021 |
0.676 ± 0.012# |
0.874 ± 0.010# |
| SPS + GF (0.15 nmol) (n = 8) |
0.059 ± 0.004 |
0.281 ± 0.017 |
0.666 ± 0.031# |
0.874 ± 0.014# |
| SPS + GF (0.30 nmol) (n = 8) |
0.054 ± 0.004 |
0.278 ± 0.019 |
0.584 ± 0.032* |
0.856 ± 0.015# |
| SPS + GF (0.50 nmol) (n = 9) | 0.053 ± 0.003 | 0.277 ± 0.015 | 0.541 ± 0.014** | 0.681 ± 0.018** |
All data are expressed as the mean ± S.E.M.
* P < 0.05, and ** P < 0.001, compared with SPS + Vehicle, respectively.
$P < 0.001, compared with SPS + Vehicle.
#P < 0.001, compared with SPS + GF (0.50 nmol).