Table 4.
Effect of GF109203X (GF) on abdominal withdrawal reflex score in response to phasic ascending colorectal distention over time following exposure to single-prolonged stress (SPS)
| Group | 10 mm Hg | 20 mm Hg | 40 mm Hg | 60 mm Hg |
|---|---|---|---|---|
| Control (n = 8) |
1.099 ± 0.120 |
2.050 ± 0.109 |
2.588 ± 0.134& |
2.850 ± 0.132& |
| SPS + Vehicle (n = 7) |
1.043 ± 0.010 |
2.100 ± 0.079 |
3.186 ± 0.083 |
3.871 ± 0.161 |
| SPS + GF (0.05 nmol) (n = 7) |
1.153 ± 0.098 |
2.071 ± 0.102 |
3.229 ± 0.068# |
3.700 ± 0.115# |
| SPS + GF (0.15 nmol) (n = 8) |
1.030 ± 0.065 |
2.088 ± 0.048 |
3.125 ± 0.084# |
3.575 ± 0.139# |
| SPS + GF (0.30 nmol) (n = 8) |
1.120 ± 0.087 |
2.038 ± 0.080 |
2.825 ± 0.103* |
3.700 ± 0.118# |
| SPS + GF (0.50 nmol) (n = 9) | 1.060 ± 0.064 | 1.967 ± 0.067 | 2.744 ± 0.100** | 3.011 ± 0.353& |
All data are expressed as the mean ± S.E.M.
* P < 0.05, and ** P < 0.01, compared with SPS + Vehicle, respectively.
#P < 0.05, compared with SPS + GF (0.50 nmol).
&P < 0.01, compared with SPS + Vehicle.