Table 4.
Top bio functions identified by ingenuity pathway analysis, from the Affymetrix ovine gene array.
|
a. R vs. C comparison | |
|---|---|
| DISEASES AND DISORDERS | P-value |
|
Immunological Disease |
|
| CSF3R, SELE, PTGDR2, IL1RL1, IGHE, VIPR2, CCL23, NR1H4, IL13RA2, CCL17, CCL22, IL13, ADRA1D, HRH1, IL17RB, CCR4, CCL2, NLRP12, CD1A, CCL26, CFH,HRH4, CYSLTR2, FCER2. |
2.73 × 10-13 - 6.71 × 10-03 |
|
Inflammatory Response |
|
| GATA1, CRLF2, NR1H4, VIPR2, IL1RL1, IL13RA2, SOCS2, P2RX1, CCL17, SLC9A4, CCL22, HRH1, NFIL, TFF2, CCL2, CD1A, HPGD, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, SELE, PTGDR2, IL5RA, CCL23, IGHE, CD200R1, CD1B, ULBP1, P2RX7, IL13, IL17RB, CCR4, NT5E, NLRP12, PILRA, CCL26, IGHA1, SH2D1B, HRH4. |
8.34 × 10-13 - 6.71 × 10-03 |
|
Hypersensitivity Response |
|
| ALOX15, PTGDR2, SELE, IL5RA, GATA1, VIPR2, IL1RL1, IGHE, CD200R1, CCL17, CCL22, P2RX7, IL13, IL17RB, CCR4, CCL2, CCL26, HRH4, FCER2 |
7.98 × 10-11 - 4.94 × 10-03 |
|
Dermatological Diseases and Conditions |
|
| ALOX15, PTGDR2, SELE, IGHE, VIPR2, NR1H4, CCL23, CCL17, CCL22, IL13, ADRA1D, HRH1, IL17RB, CCL2, CCR4, NT5E, CD1A, HPGD, HRH4, CYSLTR2, FCER2 |
1.78 × 10-09 - 6.71 × 10-03 |
|
Inflammatory Disease |
|
| CRLF2, NR1H4, IL1RL1, VIPR2, IL13RA2, CCL17, CCL22, HRH1, TH, COL6A1, CCL2, CD1A, HPGD, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, SELE, PTGDR2, IL5RA, CCL23, IGHE, CD200R1, P2RX7, IL13, ADRA1D, GLIPR2, IL17RB, CCR4, NT5E, NLRP12, CCL26. |
1.78 × 10-09 - 5.7 × 10-03 |
|
PHYSIOLOGICAL SYSTEM DEVELOPMENT AND FUNCTION |
P-value |
|
Haematological System Development and Function |
|
| GATA1, CRLF2, VIPR2, IL1RL1, SOCS2, IL13RA2, P2RX1, CCL17, CCL22, HRH1, NFIL3, TFF2, CCL2, CD1A, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, PTGDR2, SELE, IL5RA, IGHE, CCL23, CD200R1, CD1B, ULBP1, P2RX7, IL13, ZBTB32, IL17RB, CCR4, NLRP12, NT5E, MYOCD, CCL26, CYP4A11. |
4.79 × 10-12 - 6.71 × 10-03 |
|
Tissue Morphology |
|
| GATA1, CRLF2, VIPR2, IL1RL1, NR1H4, IL13RA2, SLC9A4, CCL22, TH, HRH1, NFIL3,TFF2, CCL2, CFH, SMPD3, FCER2, CSF3R, ALOX15, SELE, PTGDR2, IL5RA, IGHE, CD200R1, P2RX, IL13, OXT, IL17RB, CCR4, NLRP12, NT5E, FLNC, CNN1, CYP4A11. |
4.79 × 10-12 - 6.49 × 10-03 |
|
Humoral Immune Response |
|
| HRH1,PTGDR2, NFIL3, IL5RA, IL17RB, CRLF2, CCR4, IGHE, IL1RL1, IL13RA2, IL13, HRH4, FCER2. |
2.28 × 10-11 - 6.53 × 10-03 |
|
Immune Cell Trafficking |
|
| IL1RL1, VIPR2, SOCS2, CCL17, CCL22, HRH1, NFIL3, TFF2, CCL2, CD1A, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, PTGDR2, SELE, IGHE, CCL23, CD200R1, ULBP1, CD1B, P2RX7, IL13, IL17RB, CCR4, NT5E, NLRP12, CCL26. |
5.04 × 10-10 - 6.71 × 10-03 |
|
Cell-mediated Immune Response |
|
| PTGDR2, SELE, GATA1, CCR4, CCL2, IL1RL1, CCL23, IL13RA2, CCL17, CCL22, IL13. |
1.09 × 10-08 - 5.63 × 10-03 |
|
Lymphoid Tissue Structure and Development |
|
| CSF3R, ALOX15, SELE, GATA1, CRLF2, IL1RL1, IL13RA2, CCL17, CCL22, P2RX7, IL13, CCL2, CCR4, NT5E, CYSLTR2 |
3.82 × 10-07 - 5.7 × 10-03 |
|
Digestive System Development and Function |
|
| TFF2, NR1H4, IL13RA2, SLC9A4, IL13 |
2.41 × 10-05 - 4.94 × 10-03 |
|
b. S vs. C comparison | |
|
DISEASES AND DISORDERS |
P-value |
|
Hypersensitivity Response |
|
| FCER2, IGHE, SELE, VIPR2. |
1.76 × 10-06 - 3.31 × 10-02 |
|
Inflammatory Disease |
|
| FCER2, IGHE, IGKC, NT5E, SELE, VIPR2 |
4.64 × 10-05 - 4.10 × 10-02 |
|
PHYSIOLOGICAL SYSTEM DEVELOPMENT AND FUNCTION |
P-value |
|
Hematological System Development and Function |
|
| FCER2, IGHE, IGKC, SELE, NT5E, VIPR2. |
1.76 × 10-06 - 4.57 × 10-02 |
|
Immune Cell Trafficking |
|
| FCER2, IGHE, NT5E, SELE, VIPR2. |
1.76 × 10-06 - 4.57 × 10-02 |
|
c. R vs. S comparison | |
|
DISEASES AND DISORDERS |
P-value |
|
Gastrointestinal Disease |
|
| CCL26, IL13. |
9.85 × 10-06 - 2.62 × 10-02 |
|
Hematological Disease |
|
| CCL26, CD1A, IL13, FCER2, IGHE, IGKC, NT5E, SELE, VIPR2. |
9.85 × 10-06 - 2.62 × 10-02 |
|
PHYSIOLOGICAL SYSTEM DEVELOPMENT AND FUNCTION |
P-value |
|
Hematological System Development and Function |
|
| CCL26, CD1A, IL13. |
2.35 × 10-05 - 4.76 × 10-02 |
|
Immune Cell Trafficking |
|
| CCL26, CD1A, IL13. | 2.35 × 10-05 - 4.76 × 10-02 |