Table 1.
Descriptions of mice used in this study
|
Mouse strain |
Control mice | |
|---|---|---|
| Abbreviation | Full name, description | |
|
Apoa1 KO |
B6;129P2-Apoa1tm1Unc/J (JAX® 002055) |
C57BL/6 J |
|
Apoe KO |
B6.129P2-Apoetm1Unc/J (JAX® 002052) backcrossed to B6 |
C57BL/6 J |
| Tg(hLDLR) |
Hemizygous male offspring of hemizygous B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ (JAX® #008850) males mated with B6SJLF1/J (JAX® #100012) females |
Wild-type male littermates of Tg(hLDLR) |
|
Ldlr KO |
B6.129S7-Ldlrtm1Her/J (JAX® 002207) backcrossed to B6 |
C57BL/6 J |
|
Pcsk9 KO |
B6;129S6-Pcsk9tm1Jdh/J (JAX® 005993) backcrossed to B6 |
C57BL/6 J |
|
Pcsk9 KO IRCM |
B6 mice that lack the Pcsk9 proximal promoter and exon 1 region |
C57BL/6 J |
|
Pcsk9/Apoe double-KO |
Apoe KO mice crossed to Pcsk9 KO IRCM mice |
C57BL/6 J |
| Pcsk9/Ldlr double-KO | Ldlr KO mice crossed to Pcsk9 KO IRCM mice | C57BL/6 J |
C57BL/6 J is JAX® 000664.