TABLE 1.
Protection of mice against challenge with B. abortus 2308 after immunization with DNA vaccine coding for Cu-Zn SODa
| Vaccine injection route | Vaccine (dose [μg]) | Log10 CFU of B. abortus 2308 in spleen (mean ± SD) | Log10 units of protection |
|---|---|---|---|
| I.s. | pcDNA-SOD (10) | 4.57 ± 0.94b | 1.52 |
| I.s. | pcDNA3 (10) | 6.09 ± 0.04 | |
| I.m. | pcDNA-SOD (10) | 4.91 ± 1.50c | 1.15 |
| I.m. | pcDNA3 (10) | 6.06 ± 0.26 |
a
Mice were challenged intraperitoneally with 104 CFU of strain 2308 2 weeks prior to sacrifice.
b
P < 0.008 (significant) compared with value for control pcDNA3-treated mice.
c
P < 0.2 compared to the control group.