Table 1.

A modified excerpt of the original ‘Figure S3’ in the supplementary appendix of the CHEST trial[13]

RIFLE category and component	HES n/N (%)	Saline n/N (%)	Relative risk 95% confidence interval	p	Result
RIFLE-R (risk)	1788/3309 (54.0)	1912/3335 (57.3)	0.94 (0.90-0.98)	0.007	HES better
Creatinine increase (x1,5) from baseline	462/3149 (14.7)	415/3171 (13.1)	1.12 (0.99-1.27)	0.07	n.s.
Urine output <0.5 ml/kg/h x 6 h	1701/3230 (52.7)	1846/3266 (56.5)	0.93 (0.89-0.97)	0.002	HES better
RIFLE-I (injury)	1130/3265 (34.6)	1253/3300 (38.0)	0.91 (0.85-0.97)	0.005	HES better
Creatinine increase (x2) from baseline	245/3149 (7.8)	191/3171 (6.0)	1.29 (1.08-1.55)	0.006	Saline better
Urine output <0.5 ml/kg/h x 12 h	1077/2977 (36.2)	1200/3024 (39.7)	0.91 (0.85-0.97)	0.005	HES better

The results clearly contradict the statement in the original manuscript that in subgroup analyses “post-hoc tests show a higher relative risk of meeting the criteria for the risk of kidney dysfunction (RIFLE-R) or kidney injury (RIFLE-I) in the HES group than in the saline group”.