Table 6. Genotype and allele frequencies of polymorphisms across selenoprotein genes by serum selenium concentration in Tibetan population.
SNPs | Controls | KBD | Controls | KBD | Trend | Higher group | Lower group | Higher group | Lower group | Trend |
number | number | Freq. | Freq. | p-value | number | number | Freq. | Freq. | p-value | |
GPX1(rs1050450) | 0.932 | 0.2849 | ||||||||
CC | 147 | 155 | 0.812 | 0.816 | 174 | 125 | 0.798 | 0.839 | ||
CT | 34 | 35 | 0.188 | 0.184 | 44 | 24 | 0.202 | 0.161 | ||
TT | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
C-allele | 328 | 345 | 0.906 | 0.908 | 392 | 274 | 0.899 | 0.919 | ||
T-allele | 34 | 35 | 0.094 | 0.092 | 44 | 24 | 0.101 | 0.081 | ||
P_HWE | 0.1631 | 0.162 | 0.2849 | 0.0975 | ||||||
GPX1(rs1800668) | 0.701 | 0.924 | ||||||||
CC | 182 | 197 | 0.809 | 0.804 | 173 | 206 | 0.797 | 0.811 | ||
CT | 39 | 41 | 0.173 | 0.167 | 41 | 40 | 0.189 | 0.157 | ||
TT | 4 | 7 | 0.018 | 0.029 | 3 | 8 | 0.014 | 0.031 | ||
C-allele | 403 | 435 | 0.896 | 0.888 | 387 | 452 | 0.892 | 0.89 | ||
T-allele | 47 | 55 | 0.104 | 0.112 | 47 | 56 | 0.108 | 0.11 | ||
P_HWE | 0.2706 | 0.0121 | 0.749 | 0.002 | ||||||
GPX1(rs3811699) | 0.887 | 0.8969 | ||||||||
TT | 201 | 212 | 0.841 | 0.841 | 185 | 228 | 0.833 | 0.848 | ||
CT | 34 | 37 | 0.142 | 0.147 | 35 | 36 | 0.158 | 0.134 | ||
CC | 4 | 3 | 0.017 | 0.012 | 2 | 5 | 0.009 | 0.019 | ||
T-allele | 436 | 461 | 0.912 | 0.915 | 405 | 492 | 0.912 | 0.914 | ||
C-allele | 42 | 43 | 0.088 | 0.085 | 39 | 46 | 0.088 | 0.086 | ||
P_HWE | 0.082 | 0.347 | 0.018 | 0.8099 | ||||||
DIO2(rs225014) | 0.19 | 0.6357 | ||||||||
TT | 57 | 94 | 0.425 | 0.337 | 63 | 88 | 0.389 | 0.351 | ||
CT | 61 | 150 | 0.455 | 0.538 | 72 | 139 | 0.444 | 0.554 | ||
CC | 16 | 35 | 0.119 | 0.125 | 27 | 24 | 0.167 | 0.096 | ||
T-allele | 175 | 338 | 0.653 | 0.606 | 198 | 315 | 0.611 | 0.627 | ||
C-allele | 93 | 220 | 0.347 | 0.394 | 126 | 502 | 0.389 | 0.373 | ||
P_HWE | 0.9585 | 0.0359 | 0.0035 | 0.4085 | ||||||
TrxR2(rs5748469) | 0.461 | 0.6092 | ||||||||
AA | 136 | 209 | 0.716 | 0.749 | 154 | 191 | 0.748 | 0.726 | ||
AC | 49 | 63 | 0.258 | 0.226 | 47 | 65 | 0.228 | 0.247 | ||
CC | 5 | 7 | 0.026 | 0.025 | 5 | 7 | 0.024 | 0.027 | ||
A-allele | 321 | 481 | 0.845 | 0.862 | 355 | 447 | 0.862 | 0.85 | ||
C-allele | 59 | 77 | 0.155 | 0.138 | 57 | 79 | 0.138 | 0.15 | ||
P_HWE | 0.8164 | 0.3958 | 0.5367 | 0.606 |