. 2013 Jun 28;14:430. doi: 10.1186/1471-2164-14-430

Table 3.

Distribution of competence development-related systems in the 10 mutans streptococci strains

Name	Function	*S. mutans*	*S. mutans*	*S. mutans*	*S. mutans*	*S. mutans*	*S. mutans*	*S. mutans*	*S. mutans*	*S. ratti*	*S. sobrinus*
Name	Function	UA159	NN2025	5DC8	KK21	KK23	AC4446	ATCC 25175	NCTC 11060	DSM 20564	DSM 20742
ComA/	Competence factor & nonlantibiotic mutacin transporting ATP-binding/permease protein	SMU.286	GI\|290581206	D816_01150	D817_01300	D818_01134	D819_01163	D820_01336	D821_01208	D822_01584	D823_05343
ComA/		SMU.1881c	GI\|290579788	D816_08453	D817_08643	-	D819_07724		D821_08449	D822_08325-	D823_01400
NlmT		SMU.1881c	GI\|290579788	D816_08453	D817_08643	-	D819_07724		D821_08449	D822_08325-	D823_01400
ComB/	Accessory factor for NlmT	SMU.287	GI\|290581205	D816_01155	D817_01305	D818_01139	D819_01168	D820_01341	D821_01213	D822_01589	D823_05923
NlmE	Accessory factor for NlmT	SMU.287	GI\|290581205	D816_01155	D817_01305	D818_01139	D819_01168	D820_01341	D821_01213	D822_01589	D823_05923
ComC	S. mutans specific competence stimulating peptide, precursor	SMU.1915	GI\|290579762	D816_08588	D817_08778	D818_08368	D819_07839	D820_08520	D821_08549	-	-
SepM	cell surface-associated protease; Cleavage CSP.	SMU.518	GI\|290580977	D816_02205	D817_02448	D818_02735	D819_02254	D820_02420	D821_02274	D822_04126	D823_08607
ComD	histidine kinase	SMU.1916	GI\|290579761	D816_08593	D817_08783	D818_08373	D819_07844	D820_08525	D821_08554		D823_05333
ComE	response regulator	SMU.1917	GI\|290579760	D816_08598	D817_08788	D818_08378	D819_07849	D820_08530	D821_08559		D823_05328
ComE	response regulator	SMU.1917	GI\|290579760	D816_08598	D817_08788	D818_08378	D819_07849	D820_08530	D821_08559		D823_7992
HtrA	serine protease	SMU.2164	GI\|290581420	D816_09733	D817_00015 D817_09913	D818_00020	D819_09056	D820_09650	D821_09748	D822_05851	D823_03191
HdrM	high density responsive membrane protein	SMU.1855	GI\|290579809	D816_08353	D817_08543	D818_08143	D819_07614	D820_08345	D821_08319	D822_08240	D823_08222
HdrR	high density responsive regulator	SMU.1854	GI\|290579810	D816_08348	D817_08538	D818_08138	D819_07609	D820_08340	D821_08314	-	-
BrsM		SMU.2081	GI\|290581347	D816_09358	D817_09538	D818_09198	D819_08671	D820_09275	D821_09348	-	-
BrsR		SMU.2080	GI\|290581346	D816_09353	D817_09533	D818_09193	D819_08666	D820_09270	D821_09343	D822_05085	-
OppD	oligopeptide ABC transporter	SMU.258	GI\|290581226	D816_01025	D817_01175	D818_01039	D819_01063	D820_01211	D821_01051	D822_05611	D823_04322
ComS	comX-inducing peptide (XIP) precursor	NC_004350.2	NC_013928.1	D816_00277	D817_00297	D818_00297	D819_00203	D820_00247	D821_00253	D822_01077	-
ComS	comX-inducing peptide (XIP) precursor	(62613 - 62666)a	(60952- 61005)b	D816_00277	D817_00297	D818_00297	D819_00203	D820_00247	D821_00253	D822_01077	-
ComR	ComS receptor	SMU.61	GI\|290579576	D816_00275	D817_00295	D818_00294	D819_00200	D820_00245	D821_00250	D822_01080
ComX(SigX)	competence-specific sigma factor	SMU.1997	GI\|290579687	D816_08973	D817_09163	D818_08748	D819_08219	D820_08900	D821_08929	D822_07328	D823_08887
ComEA	competence protein	SMU.625	GI\|290580890	D816_02675	D817_02923	D818_03217	D819_02694	D820_02880	D821_02784	D822_02674	D823_08107
ComEC	competence protein; possible integral membrane protein	SMU.626	GI\|290580889	D816_02680	D817_02928	D818_03222	D819_02699	D820_02885	D821_02789	D822_02679	D823_08117
CoiA	competence protein CoiA	SMU.644	GI\|290580870	D816_02775	D817_03018	D818_03322	D819_02786	D820_02970	D821_02879	D822_02739	D823_01025
EndA	competence associated membrane nuclease (DNA-entry nuclease)	SMU.1523	GI\|290580108	D816_06842	D817_07008	D818_06659	D819_06647	D820_06860	D821_06857	D822_03254	D823_09687
ComG	competence protein G	SMU.1981c	GI\|290579702	D816_08898	D817_09088	D818_08673	D819_08144	D820_08825	D821_08854	D822_07418	D823_01170
ComYD	competence protein ComYD	SMU.1983	GI\|290579700	D816_08908	D817_09098	D818_08683	D819_08154	D820_08835	D821_08864	D822_07408	D823_01160
ComYC	competence protein ComYC	SMU.1984	GI\|290579699	D816_08913	D817_09103	D818_08688	D819_08159	D820_08840	D821_08869	D822_07403	D823_01155
	possible competence-induced protein	SMU.2075c	GI\|290581342	D816_09328	D817_09508	D818_09168	D819_08641	D820_09245	D821_09318	D822_05110	D823_03558
CinA	competence damage-inducible protein A	SMU.2086	GI\|290581351	D816_09383	D817_09563	D818_09218	D819_08691	D820_09295	D821_09368	D822_05060	D823_03593
ComYB	competence protein; general (type II) secretory pathway protein	SMU.1985	GI\|290579698	D816_08918	D817_09108	D818_08693	D819_08164	D820_08845	D821_08874	D822_07398	D823_01150
ComYA	late competence protein; type II secretion system protein	SMU.1987	GI\|290579697	D816_08923	D817_09113	D818_08698	D819_08169	D820_08850	D821_08879	D822_07393	D823_01145
ComFC	late competence protein required for DNA uptake	SMU.499	GI\|290580999	D816_02100	D817_02348	D818_02650	D819_02154	D820_02290	D821_02159	D822_06218	D823_02981
ComFA	late competence protein F	SMU.498	GI\|290581000	D816_02095	D817_02343	D818_02645	D819_02149	D820_02285	D821_02154	D822_06223	D823_02986
CinA	competence damage-inducible protein A;	SMU.2086	GI\|290581351	D816_09383	D817_09563	D818_09218	D819_08691	D820_09295	D821_09368	D822_05060	D823_03593

In the case that more than one paralogs were found, the most similar ortholog is marked in italic. The rows related to highly conserved ‘late-competence genes’ were shown in boldface. The missing of ComDE in S. ratti DSM 20564 has been published in our previous study [26].

^alocation of comS in S. mutans UA159.

^blocation of comS in S. mutans NN2025.