Table 2. GO term enrichment analysis using DAVID.

GO annotation		Genes	P value	Corrected P value
Upregulated genes (423 DAVID IDs)
1	GO:0043122~regulation of I-kappaB kinase/NF-kappaB cascade	CD40, TFG, TNFSF10, CASP1, TBK1, PLK2, TRIM38, NOD1, RHOC, HTR2B, WLS, CARD8, SHISA5, TRADD, ZDHHC17	4.87E-07	8.50E-04*
2	GO:0042981~regulation of apoptosis	MEF2C, LOC100289713, NGFRAP1, ARHGEF6, NOTCH1, SH3GLB1, TNFSF13B, B4GALT1, TNFSF10, IDO1, BNIP3, APH1A, NOD1, ADAM17, CARD8, NGFR, SOCS3, KALRN, TRADD, SOX9, MSX2, AEN, CADM1, BARD1, CASP4, CREB1, CD38, CASP1, AKT1, CASP3, MCL1, JAK2, DPF2, TXNIP, FAS, TIA1, ANGPTL4, EYA1, YWHAZ, NTRK1, SIRT1, BCL2L13	1.10E-05	1.92E-02*
3	GO:0009967~positive regulation of signal transduction	CD40, BMPR1A, TFG, HIF1A, FKBP8, TNFSF10, CASP1, JAK2, TBK1, PLK2, TRIM38, NOD1, HTR2B, ADAM17, JAG1, RHOC, WLS, RICTOR, SMAD4, SHISA5, TRADD, ZDHHC17	1.18E-05	2.06E-02*
Downregulated genes (598 DAVID IDs)
1	GO:0034660~ncRNA metabolic process	CARS2, FARSB, POP7, TSEN2, WDR12, EXOSC1, DUS3L, TARSL2, ADAT2, RPL35A, PDCD11, PIWIL1, IMP4, QTRTD1, TRMT10C, PUS3, EXOSC7, FTSJ1, MKI67IP, RPL7, DIMT1	2.42E-05	4.14E-02*
2	GO:0022613~ribonucleoprotein complex biogenesis	WDR12, GEMIN6, RRS1, EXOSC1, NCBP1, SURF6, RPL35A, TSR1, IMP4, PDCD11, GEMIN5, EXOSC7, FTSJ1, NUFIP1, MRTO4, RPL7, BYSL, DIMT1	3.72E-05	6.37E-02
3	GO:0042254~ribosome biogenesis	WDR12, RRS1, EXOSC1, SURF6, RPL35A, TSR1, IMP4, PDCD11, FTSJ1, EXOSC7, MRTO4, RPL7, BYSL, DIMT1	8.01E-05	1.37E-01
4	GO:0006457~protein folding	BAG2, DNAJC12, SEC63, RUVBL2, FKBP7, GRPEL1, APCS, SACS, PFDN6, HSPBP1, PPIF, PPID, CCT6A, URI1, PPIH	7.06E-04	1.20

The Entrez Gene IDs of upregulated and downregulated genes were analyzed separately for biological process enrichment using DAVID. Enriched GO terms are ranked in order of decreasing significance. The gene IDs in each GO category are listed alongside the corrected (FDR) and uncorrected P values. For clarity redundant terms were removed. * Pass FDR correction of 0.05.