Table 4. Gene expression changes associated with TGF-β and Notch signaling pathways in TCF4-knockdown cells.
| Gene | FC | P value | Description |
|---|---|---|---|
| TGF-β signaling pathway | |||
| BMP7 | -3.94 | 1.34E-04 | BMP Ligand |
| BMPR1A | 2.46 | 1.81E-05 | Tyrosine kinase receptor (BMP) |
| SMAD2 | -2.15 | 4.38E-04 | R-SMAD (TGF/Nodal) |
| SMAD4 | 1.49 | 4.71E-04 | co-SMAD |
| SMAD7 | 1.38 | 3.97E-04 | I-SMAD |
| SMAD6 | 1.23 | 1.04E-02* | I-SMAD |
| SMAD1 | 1.28 | 9.59E-03* | R-SMAD (BMPR1) |
| NODAL | -1.25 | 2.27E-04 | Ligand (Nodal) |
| INHBA | -2.38 | 2.68E-07 | Ligand (Activin A) |
| LEFTY1 | -2.81 | 3.37E-04 | Ligand (Inhibitor of Nodal) |
| Notch signaling pathway | |||
| NOTCH1 | 2.40 | 1.02E-04 | Ligand receptor |
| NOTCH2 | -1.43 | 8.48E-03* | Ligand receptor |
| JAG1 | 2.59 | 4.61E-04 | Ligand receptor (inhibitor of Notch) |
| ADAM17 | 1.44 | 3.83E-04 | metallopeptidase (Notch-cleavage) |
| APH1A | 1.64 | 1.57E-04 | γ-secretase complex (Notch-cleavage) |
| HES1 | 1.65 | 4.67E-05 | Notch effector |
| HES7 | -1.54 | 6.40E-03* | Notch effector |
Gene expression changes in manually curated signaling pathways in TCF4-knockdown cells. The data are presented as statistically significant (FDR 0.01) gene expression changes (fold change) for the genes in the TGF-β and Notch signaling pathways. * Pass FDR correction of 0.05.