Table 5. Gene expression changes associated with the IGF signaling pathway in TCF4-knockdown cells.
| Gene | Fold change | P value | Description |
|---|---|---|---|
| IGF2 | -5.22235 | 1.52E-06 | IGF ligand |
| IGFBP5 | 4.90659 | 2.35E-05 | IGF carrier protein |
| IGFBP3 | 1.28834 | 1.17E-02* | IGF carrier protein |
| IGFBP4 | 2.59348 | 3.09E-03* | IGF carrier protein |
| IGFBPL1 | -1.43755 | 8.52E-05 | |
| GRB14 | -3.08126 | 1.79E-05 | Receptor-bound protein (inhibitor) |
| GRB7 | -1.22578 | 1.95E-04 | Receptor-bound protein (inhibitor) |
| PIK3CG | -1.75377 | 9.67E-03* | Signal transduction (kinase) |
| PIK3CA | 1.58222 | 6.16E-04* | Signal transduction (kinase) |
| PIK3C2B | -1.45293 | 5.42E-03* | Signal transduction (kinase) |
| PIK3CD | -1.30542 | 7.37E-03* | Signal transduction (kinase) |
| PDPK1 (PDK1) | -1.98747 | 8.88E-05 | AKT inhibition (kinase) |
| AKT1 | 1.36045 | 3.53E-04 | Signal transduction (kinase) |
| YWHAG | -1.9787 | 7.64E-05 | Regulatory co-factor |
| YWHAZ | 1.2674 | 3.63E-04 | Regulatory co-factor |
| FOXO1A | 1.6064 | 3.75E-03* | Transcription factor |
| FOXO3B | -1.72656 | 3.65E-03* | Transcription factor |
| RPS6KB1 (S6K1) | -1.2898 | 3.83E-03* | Ribosomal subunit kinase |
| RPS6KC1 | 1.78394 | 4.15E-03* | Ribosomal subunit kinase |
| RPS6KA3 | 1.47367 | 6.83E-03* | Ribosomal subunit kinase |
| RPS6KA1 | -1.32884 | 2.57E-03* | Ribosomal subunit kinase |
Gene expression changes in the manually curated IGF signaling pathway in TCF4-knockdown cells. The data are presented as statistically significant (FDR 0.01) gene expression changes sorted by fold change for the genes in the IGF signaling pathway [29]. * Pass FDR correction of 0.05.