Figure 3.
Immunostaining of neurovascular remodeling in peri-infarct cortex. A, Ki67 colocalization with CD31-positive endothelial cells suggested the presence of new microvessel formation during the delayed recovery phase of the peri-infacrt cortex. B, RECA-positive microvessels were reduced by JNK inhibition. C, MMP-9 levels in GFAP-positive astrocytes were reduced by JNK inhibition. D, Quantitative densitometry of RECA immunostaining. E, Quantitative densitometry of MMP-9 immunostaining. *p < 0.05 comparing vehicle controls versus SP600125-treated rats (n = 8 per group).