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. 2012 Jun 13;32(24):8112–8115. doi: 10.1523/JNEUROSCI.0219-12.2012

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Copyright © 2012 the authors 0270-6474/12/328112-04$15.00/0

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Figure 4. — Effects of JNK inhibition on in vitro angiogenesis. A, Representative Matrigel tube formation images in RBE4 rat brain endothelial cells. B, Quantified tube formation rates. *p < 0.05 comparing vehicle controls versus SP600125-treated rats (n = 3 independent experiments in triplicate). C, SP600125 was not cytotoxic according to a standard LDH release assay. D, Western blots showed increased phospho-JNK during Matrigel tube formation. Reduction of tube formation by SP600125 was accompanied by suppression of phospho-JNK. Con, Control; Stim, stimulation; SP, SP600125; p, phospho.