Figure 5.

Determination of DA and its metabolites in D2R^floxflox, D2R^{floxflox/En1Cre/+}, and D2R^{floxflox/D1Cre/+} mice. Values indicate the percentage of DA, DOPAC, and HVA with respect to D2R^floxflox levels, which were arbitrarily set at 100%. A–C, Determination were made by HPLC on extracts from tissue punches of DSt (A), NAcc (B), and PFC (C) from D2R^floxflox (black bars) and D2R^{floxflox/En1Cre/+} (white bars). D–F, DSt (D), NAcc (E), and PFC (F) from D2R^floxflox (black bars) and D2R^{floxflox/D1Cre/+} (gray bars). Statistical analyses were performed by the Student's t test: *p < 0.05; **p < 0.01 (n = 7–8).