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. 2012 Jul 18;32(29):10045–10052. doi: 10.1523/JNEUROSCI.0174-12.2012

Figure 5.

Figure 5.

Kv1.4- and Kv4.2-encoded IA channels set the period and amplitude of circadian firing patterns in SCN neurons. Discharge profiles were recorded continuously over 5 d from dispersed SCN neurons as described previously (see Materials and Methods). A, Representative recordings from three SCN neurons of each of the four genotypes are illustrated. The circadian firing periods of individual cells were measured and averaged over the 5 d of recordings, and cumulative frequency plots of the measured mean values for each of the four genotypes are presented in B. Nearly 40% of Kv1.4−/− (n = 200) and Kv4.2−/− (n = 130) SCN neurons displayed markedly shorter circadian firing periods than WT (n = 106) or Kv4.3−/− (n = 30) SCN neurons. C, Plotting the cumulative distribution of mean peak and trough firing rates illustrates the marked increases in both (peak and trough) firing rates in Kv1.4−/− (n = 200) and Kv4.2−/− (n = 130) compared with WT (n = 106) or Kv4.3−/− (n = 30) SCN neurons.