Figure 4.
Electron micrographs of CA1 neurons from apoE−/− slices incubated with ZPAD for 6 days. (A) Survey micrograph showing a primary dendrite emerging from a neuronal cell body. Filamentous material (arrows) occupies more than half of the cross-section of the dendrite. (B) Enlargement of bundled filaments in the proximal dendrite from A. (C) Another example of a dendrite with filaments that form bundles that crisscross each other (arrows). (Bar = 2 μm in A, 0.75 μm in B, and 0.4 μm in C.)
