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. 2004 Apr;72(4):2131–2139. doi: 10.1128/IAI.72.4.2131-2139.2004

FIG. 1.

FIG. 1.

Impaired TNF and IL-12 p40 production in TLR2- and MyD88-deficient macrophages and DCs infected with Listeria (LM) or stimulated with HKLM in vitro. Shown are in vitro responses of BMDM and BMDC to HKLM, Listeria, LTA, and LPS by TLR2+/+ (black bars), TLR2−/− (white bars), and MyD88−/− (hatched bars) mice. Macrophages (A and C) and DCs (B and D) were stimulated for 24 h with Listeria (2×), HKLM (200×), BLP (0.5 μg/ml), and LPS (100 ng/ml). The concentrations of TNF (A and B) and IL-12 p40 (C and D) in supernatants were determined by ELISA. Results are from one representative experiment of three independent experiments and are expressed as means ± standard deviations (SD). *, P < 0.05; **, P < 0.01.