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. 2012 Oct 3;32(40):13668–13678. doi: 10.1523/JNEUROSCI.1551-12.2012

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Copyright © 2012 the authors 0270-6474/12/3213668-11$15.00/0

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Figure 7. — Opioid administration caused changes in the responses of RM cells to noxious stimulation in the lightly anesthetized rat that resemble those observed in the unanesthetized mouse. A, B, The average firing rates (A) and evoked responses (B) of RM ON (51 trials in 17 cells from 17 rats) and OFF cells (22 trials in 9 cells from 9 rats) are shown before and after intracerebroventricular DAMGO administration in the rat. C, After DAMGO administration, ON cells were responsive only when a withdrawal occurred (35 of 51 trials). D, Pretrial ON cell activity was not correlated with peak withdrawal magnitude. E, F, The ON cell burst was correlated with maximal EMG amplitude both before (E) and after (F) DAMGO administration. Symbols are as in Figure 4, B and C. G, There was no correlation between withdrawal latency and pretrial OFF cell activity. H, There was a correlation between withdrawal latency and the latency to the OFF cell pause. I, DAMGO administration disrupted the correlation between withdrawal and OFF cell pause latencies. *p < 0.05; **p < 0.01; ***p < 0.001. A–I are from 26 rats and includes data from 17 ON cells and 9 OFF cells.