Figure 1.

The E2-regulated, MAPK-dependent genes zenk, c-fos, and arc lack the estrogen responsive element (ERE) in their promoters. Shown is a schematic representation of a 2 kb sequence upstream of the transcription start site, which includes the promoters of the MAPK-dependent genes zenk (A), c-fos (B), and arc (C). Vertical bars of different colors denote identified transcription factor binding sites and their relative positions. Depicted in this figure are the putative binding sites for 12 transcription factors that were both shared across the three genes (zenk, c-fos, and arc), and conserved across three species (zebra finch, chicken, and mouse). Binding sites that were unique to each of these three genes (but conserved across species) can be found in Table 1. Note that the ERE is not found in the promoters of each of the three genes.