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Unique metabolism of S-1. S-1 (FT, CDHP, Oxo) is an oral ‘DPD inhibitory fluoropyrimidine’ (DIF). 5-FU, fluorouracil; CDHP, 5-chloro-2,4-dihydroxypyridine; DPD, dihydropyrimidine dehydrogenase; GI, gastrointestinal; OPRT, orotate phosphoribosyltransferase; Oxo, potassium oxonate.
