Table 2.
Indication | Medication | Dosing Regimen |
---|---|---|
Primary infection | ||
Adult | Acyclovir | 400 mg, PO, 3×/d, or 200 mg, PO, 5×/d for 7-10 d |
Famciclovir | 250 mg, PO, 3×/d for 7-10 d | |
Valacyclovir | 1000 mg, PO, 2×/d for 7-10 d | |
≤ 12 years old | Acyclovir | 40-80 mg/kg daily in 3 divided doses for 5-10 d (max, 1 g/d) |
Valacyclovir | 20 mg/kg, PO, 3×/d for 5-10 d | |
Recurrent infection | ||
Adulta | Acyclovir | 800 mg, PO, 2×/d for 5 d, or 400 mg, PO, 3×/d for 5 d |
Famciclovir | 125 mg, PO, 2×/d for 5 d, or 1 g, PO, 2× for 1 d | |
Valacyclovir | 1 g, PO, daily for 5 d, or 500 mg, PO, 2×/d for 3-7 d | |
Prophylaxis | ||
> 12 years oldb | Acyclovir | 400 mg, PO, 2×/d |
Famciclovir | 250 mg, PO, 2×/d | |
Valacyclovir | 500 mg, PO, once daily, or 1 g, PO, once daily |
PO, orally.
Same as for primary infection, ≤ 12 years old.
Insufficient evidence to recommend use of prophylaxis in children < 12 years old.