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. 2013 Aug 5;110(34):13863–13868. doi: 10.1073/pnas.1304529110

Fig. 4.

Fig. 4.

Inhibition of PI3K/Akt activation in TNFSF15-stimulated, ubiquitin-assisted mFlt1 degradation in EPC. (A) Effect of ubiquitin inhibitor PYR-41 on TNFSF15-induced mFlt1 degradation. (B) Effect of proteasome inhibitor MG132 on TNFSF15-induced mFlt1 degradation. (C) Inhibition of Akt phosphorylation by TNFSF15 treatment and Akt rephosphorylation upon TNFSF15 removal. (D) Effect of PI3K inhibitor LY294002 on TNFSF15-induced mFlt1 degradation and Akt phosphorylation. Bar graphs represent quantitative analyses of Western blotting data from two independent experiments. Data are mean ± SD. **P < 0.01, Student t test.