Fig. 4.

TGRL uptake increases membrane CD11c and VLA-4 affinity on Mon2. (A) CD11c expression (left axis, solid colors) and LDV-FITC expression (right axis, checkered boxes) on Mon2 following incubation with postprandial TGRL. Significance for TGRL alone, MCP-1 (30 nM), or Mn²⁺ (1 mM) treated monocytes was compared versus control (open white box). Blocking with RAP or PLC was compared against TGRL alone. Significance was determined by one-way ANOVA with Tukey posttest, *P < 0.05, **P < 0.01. (B) Percent change from baseline levels of CD11c receptor expression on Mon2 and all other monocytes plotted as a function of the mean triglyceride concentration of TGRL particles incubated with monocytes.