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. 2013 Aug 5;110(34):E3235–E3242. doi: 10.1073/pnas.1301125110

Fig. 5.

Fig. 5.

The descending dopaminergic (DA) projection from the PT to the MLR controls locomotion. DA or the D1 antagonist SCH 23390 was microinjected in the MLR with a Picospritzer in a semi-intact preparation. (A–C) Microinjection of DA (5 mM; Materials and Methods) in the MLR increased the locomotor and reticulospinal (RS) activities elicited by PT stimulation (10-s train, 5 Hz, 6 µA, 2-ms pulses). (D–F) Microinjection of the D1 antagonist SCH 23390 (500 µM; Materials and Methods) in the MLR decreased the locomotor output elicited by PT stimulation (10-s train, 5 Hz, 11 µA, 2-ms pulses). In both cases, the locomotor response and the corresponding reticulospinal activity are illustrated. Blue indicates control condition, red indicates microinjection of DA compounds in the MLR, and green indicates washout.