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. Author manuscript; available in PMC: 2014 Jul 17.
Published in final edited form as: Cell Host Microbe. 2013 Jul 17;14(1):26–37. doi: 10.1016/j.chom.2013.06.007

Figure 1. Probiotic E. coli Nissle 1917 reduces S. Typhimurium fecal shedding.

Figure 1

(A) The concentration of iron in fecal samples collected from mock-infected (n = 4) or S. Typhimurium-infected (n = 4) C57BL/6 mice four days post-infection. Bars represent geometric means ± standard deviation. (B–E) 129X1/SvJ mice were infected with S. Typhimurium and either untreated (B) or treated with one dose of E. coli Nissle wild-type (C) or tonB mutant (D) three days after infection. S. Typhimurium (black circles), E. coli Nissle wild-type or tonB mutant (white circles) were enumerated in the colonic contents. (E) Ratio of colony forming units (CFU) recovered from fecal samples of mice infected with S. Typhimurium that were untreated compared with mice treated with one dose of either E. coli Nissle wild-type or tonB mutant three days after infection. Ratios 2 days after infection (i.e., 1 day before treatment) and 22 days after infection are shown. Bars represent geometric means ± standard deviation. Data are representative of n=2 experiments. STM=S. Typhimurium; EcN=E. coli Nissle. Significant difference is indicated by ** (P value ≤ 0.01). (See also Figure S1 and Table S1).