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. Author manuscript; available in PMC: 2014 Jul 17.
Published in final edited form as: Cell Host Microbe. 2013 Jul 17;14(1):26–37. doi: 10.1016/j.chom.2013.06.007

Figure 6. E. coli Nissle 1917 reduction of S. Typhimurium intestinal colonization requires functional lipocalin-2 and is independent of the time of administration.

Figure 6

(A) C57BL/6 mice were infected with S. Typhimurium alone or co-administered with commensal E. coli K-12. CFU in colonic contents were enumerated at 48h, 72h and 96h post-infection. STM (black circles) and E. coli K-12 (white circles) counts are shown. (B) C57BL/6 Lcn2−/− mice were infected with S. Typhimurium alone or co-administered with wild-type E. coli Nissle. CFU in colonic contents were enumerated at 48h, 72h and 96h post-infection. S. Typhimurium (black circles) and E. coli Nissle (white circles) counts are shown. (C) C57BL/6 mice were administered a single dose of E. coli Nissle wild-type or mock, three days before being infected with S. Typhimurium. Streptomycin treatment was performed one day prior to S. Typhimurium infection. CFU in colonic contents were enumerated at 2, 3 and 4 days post-infection. S. Typhimurium (black circles) and E. coli Nissle (white circles) counts are shown. K12=E. coli K12; STM=S. Typhimurium; EcN=E. coli Nissle. (See also Figure S5).