Figure 7. Ratios of S. Typhimurium and E. coli Nissle in the acute colitis model.
Ratio of the CFU recovered from the fecal samples of mice infected with S. Typhimurium that were untreated in comparison with mice that were administered one dose of either E. coli Nissle wild-type, the tonB mutant, or the iroN fuyA iutA chuA (Δ4) mutant at the time of infection. (A, C, E) Ratio of S. Typhimurium CFU at 48 hours (A), 72 hours (C), 96 hours (E) post infection. (B, D, F) Competitive index (CI) in the indicated mixed infection was calculated by dividing the output ratio (E. coli Nissle CFU / S. Typhimurium CFU in the colonic contents of mice at the indicated time points by the input ratio (E. coli Nissle CFU / S. Typhimurium CFU). CI of the indicated E. coli Nissle strain versus S. Typhimurium at 48 hours (B), 72 hours (D), 96 hours (F) post infection. Bars represent geometric means ± standard deviation. Significant difference is indicated by * (P value ≤ 0.05) or ** (P value ≤ 0.01).