Table 1.
Chromosome regions containing 3 or more SNPs within 50 kb of each other that are associated with symptom count at inflation corrected p<0.0001 and the comparison of association between alcohol dependence symptom count and DSM-IV alcohol dependence in these regions.
| Chromosome location | SNP | Position (hg19) | Gene/Transcript | Gene/Transcript position | Alcohol dependence symptom count | DSM-IV alcohol dependence | |||
|---|---|---|---|---|---|---|---|---|---|
| Effect | p value | Corrected p value | Effect | p value | |||||
| 1q32.3 | rs612414 | 212602176 | NENF | 212606229---212619721 | −0.15 | 1.07E-05 | 7.85E-05 | −0.26 | 2.25E-03 |
| rs583058 | 212610755 | NENF | −0.13 | 1.42E-05 | 9.92E-05 | −0.23 | 9.44E-04 | ||
| rs4804 | 212619339 | NENF | −0.14 | 8.36E-06 | 6.44E-05 | −0.24 | 7.15E-04 | ||
| rs483954 | 212620214 | NENF | −0.15 | 3.90E-06 | 3.47E-05 | −0.27 | 6.30E-04 | ||
|
| |||||||||
| 2q37.3 | rs896543 | 237509207 | CXCR7 | 237478380---237490997 | −0.22 | 4.75E-07 | 6.29E-06 | −0.56 | 4.35E-06 |
| rs6431476 | 237517937 | CXCR7 | −0.20 | 1.14E-06 | 1.28E-05 | −0.51 | 3.92E-06 | ||
| rs7594454 | 237537935 | CXCR7 | −0.18 | 2.60E-06 | 2.49E-05 | −0.44 | 3.05E-05 | ||
|
| |||||||||
| 3q24 | rs7431637 | 143049769 | SLC9A9 | 142984064---143567373 | −0.14 | 7.58E-06 | 5.95E-05 | −0.31 | 3.60E-04 |
| rs10446322 | 143068250 | SLC9A9 | −0.15 | 1.73E-06 | 1.80E-05 | −0.33 | 5.77E-05 | ||
| rs868702 | 143085345 | SLC9A9 | 0.15 | 1.73E-06 | 1.79E-05 | 0.34 | 2.58E-05 | ||
|
| |||||||||
| 4q21.21 | rs12513014 | 81061422 | intergenic | 0.16 | 1.38E-05 | 9.70E-05 | 0.35 | 1.02E-03 | |
| rs13102102 | 81073672 | intergenic | 0.14 | 1.11E-05 | 8.12E-05 | 0.35 | 1.37E-05 | ||
| rs13138779 | 81087073 | intergenic | 0.21 | 9.75E-06 | 7.30E-05 | 0.49 | 7.69E-04 | ||
|
| |||||||||
| 9p22.2 | rs10963462 | 18130036 | intergenic | −0.18 | 6.22E-06 | 5.07E-05 | −0.40 | 1.18E-05 | |
| rs763976 | 18134914 | intergenic | −0.17 | 1.00E-05 | 7.46E-05 | −0.40 | 7.40E-06 | ||
| rs12006002 | 18166899 | intergenic | 0.15 | 7.24E-06 | 5.73E-05 | 0.45 | 4.87E-07 | ||
|
| |||||||||
| 15q14 | rs7168475 | 38960882 | C15orf53 | 38988799---38992239 | −0.18 | 1.98E-06 | 2.00E-05 | −0.39 | 4.66E-04 |
| rs12903120 | 38988097 | C15orf53 | −0.18 | 5.45E-08 | 1.09E-06 | −0.38 | 7.62E-06 | ||
| rs12916379 | 38991520 | C15orf53 | −0.17 | 1.74E-07 | 2.79E-06 | −0.36 | 4.06E-05 | ||
| rs2132157 | 38992547 | C15orf53 | −0.17 | 1.92E-07 | 3.02E-06 | −0.36 | 4.35E-05 | ||
|
| |||||||||
| 15q24.2 | rs2029519 | 75415962 | intergenic | 0.14 | 1.07E-05 | 7.87E-05 | 0.29 | 1.60E-03 | |
| rs4479194 | 75422131 | intergenic | 0.15 | 5.27E-06 | 4.43E-05 | 0.30 | 1.02E-03 | ||
| rs7172677 | 75424593 | intergenic | 0.15 | 7.15E-06 | 5.68E-05 | 0.32 | 5.35E-04 | ||
|
| |||||||||
| 20q11.22 | rs6060124 | 33536897 | GSS | 33516236---33543601 | 0.16 | 4.41E-07 | 5.92E-06 | 0.33 | 2.03E-04 |
| rs6088664 | 33551100 | MYH7B | 33543704---33590240 | −0.15 | 3.23E-06 | 2.98E-05 | −0.27 | 1.91E-03 | |
| rs6579204 | 33553677 | MYH7B | 0.15 | 4.54E-06 | 3.93E-05 | 0.29 | 1.25E-03 | ||