Figure 6.
Protein networks represented by the candidate proteins identified in the SKF81297-treated samples. (A) Protein network involved in cellular assembly and organization, nervous system development and function, cell-to-cell signaling and interaction consisting of the following molecules: ATPase, Ca2+ transporting, plasma membrane 2 (ATP2B2); ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 (ATP6V0D1); atypical protein kinase C; bassoon (BSN); Ca2 ATPase; calcium channel, voltage-dependent 2/δ subunit 1 (CACNA2D1); cell adhesion molecule 1 (CADM1); cell adhesion molecule 3 (CADM3); discs, large homolog 1 (Drosophila) (DLG1); discs, large homolog 2 (Drosophila) (DLG2); glycogen synthase kinase 3 α(GSK3); H+-exporting ATPase; hippocalcin (HPCA); potassium voltage-gated channel, shaker-related subfamily, B member 1 (KCNAB1); potassium voltage-gated channel, shaker-related subfamily, B member 2 (KCNAB2); potassium large conductance calcium-activated channel, subfamily M, α member 1 (KCNMA1); microtubule-associated protein 1A (MAP1A); microtubule-associated protein τ (Mapt); N-type Calcium Channel; phosphofructokinase, liver, (PFKL); protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF) interacting protein (liprin), α 3, (PPFIA3); Ppp2c; PRKAC; protein kinase, cAMP-dependent, regulatory, type II, B (PRKAR2B); RAB2A, member RAS oncogene family (RAB2A); regulating synaptic membrane exocytosis 1 (Rims1); Ras and Rab interactor 1 (RIN1); rabphilin 3A homolog (mouse) (RPH3A); SERCA; synaptosomal-associated protein, 25kDa (SNAP25); syntaxin 1A (brain) (STX1A); synaptic vesicle glycoprotein 2B (SV2B); unc-13 homolog A (C. elegans) (UNC13A). (B) Protein network involved in protein synthesis, cellular assembly and organization, genetic disorder: 19S proteasome; 26S Proteasome; 60S ribosomal subunit; adenosylhomocysteinase (AHCY); Angiotensin II receptor type 1; ADP-ribosylation factor 2 (Arf2); ADP-ribosylation factor 3 (ARF3); Arf; Rho/Rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2); Cdc2; CSE1; chromosome segregation 1-like (yeast) (CSE1L); DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked (DDX3X); dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1); eukaryotic translation elongation factor 1 γ (EEF1G); eukaryotic translation initiation factor 4A2 (EIF4A2); Eif4g; ribosomal protein L7A pseudogene (Gm5619/Gm5845); heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) (HNRNPD); importin 5 (IPO5); Mapk; Mediator; RAN, member RAS oncogene family (RAN); ribosomal proteins RPL4; RPL13; RPL15; RPL17; RPL19; RPL24; RPL35; RPL13A; RPL18A; RPS8; RPS25; serine/arginine-rich splicing factor 1 (SRSF1); tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, γ polypeptide (YWHAG). Icons in grey, molecules present in both SKF81297- and vehicle-treated samples; icons in magenta, proteins present in SKF81297-treated samples only; icons in white, molecules not identified in either sample.