Skip to main content
. Author manuscript; available in PMC: 2013 Aug 25.
Published in final edited form as: J Immunol. 2010 Feb 1;184(5):2561–2571. doi: 10.4049/jimmunol.0902322

FIGURE 8.

FIGURE 8

Immunized HLA Tg rabbits with more epitope-specific CD8+ T cells have less corneal disease. A, The results obtained from the HLA Tg rabbits that were immunized and ocularly challenged with HSV-1 (from Figs. 6 and 7) were divided into two groups, based on the amount of corneal disease on day 12 p.i. (low disease, < 10 mm2; high disease, > 30 mm2). The average absolute number of tetramer positive/CD8+ T cells specific to each of the three human CD8+ T cell epitopes are shown. The results are representative of two independent experiments. B, The relative amount of IFN-γ mRNA produced by conjunctiva- and cornea-derived CD8+ T cells of low and high corneal disease eyes was determined by quantitative RT-PCR.