Figure 1.

Utilizing both mechanistic and unbiased miRNA studies to understand disease. Using global miRNA profiling of ventricles during development of severe hypertrophic cardiomyopathy and heart failure^{7, 13} with mechanistic observations from specific miRNAs⁵ and predicted targets, combinatorial approaches can be pursued that could yield increasingly relevant in vivo data. These approaches acknowledge that there is both increased and decreased miRNA expression in disease settings and these miRNAs may target a broad number of compensatory and non-compensatory pathways.