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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Cancer Res. 2013 Jun 6;73(15):4697–4710. doi: 10.1158/0008-5472.CAN-13-0930

Figure 1. Progesterone therapy resulted in resolution of endometrial tumors initiated by epithelial loss of PTEN (PTENKO).

Figure 1

(A) Schema for in vivo therapy. (B) Large tumors were found in placebo treated mice (n=8) (a&b). Resolution of tumors was noted with progesterone therapy (n=8) (c&d). (C) Residual cysts in progesterone treated mice contained a single epithelial layer compared to persistent tumor epithelia in placebo treated controls (e vs. a). PTEN was absent in all epithelia (b&f). Epithelial and stromal ERα (c&g) and PR (d&h) were detected with progesterone or placebo. (D) A decrease in proliferating epithelia was detected upon progesterone administration (a vs. b). Scale bars equal 2 mm in B, and 100 μm in C&D.