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. 2004 Apr;48(4):1382–1383. doi: 10.1128/AAC.48.4.1382-1383.2004

TABLE 1.

Fungal burdens in kidneys of mice infected with C. albicans

Isolate	Caspofungin MIC (μg/ml)		Inoculum size (CFU/mouse [10⁵])	Median (range) log₁₀ no. of CFU/pair of kidneys
	RPMI medium	AM3		Control	Caspofungin at:					Fluconazole at 5 mg/kg BID
	RPMI medium	AM3		Control	0.0625 mg/kg	0.125 mg/kg	0.25 mg/kg	0.5 mg/kg	1 mg/kg	Fluconazole at 5 mg/kg BID
1	0.25	<0.125	2.9	5.8 (5.5-7.4)	5.1 (2.6-5.8)^a	3.9 (0-5.1)^a	3.8 (2.4-6.2)^a	2.6 (1.6-2.9)^a	2.9 (2.4-3.6)^a	5.9 (5.5-6.5)
2	0.25	<0.125	6	5.6 (2.4-6.4)	5.6 (2.4-6.4)	2.4 (1.9-3.6)^a	2.1 (2.0-2.9)^a	1.9 (1.4-3.4)^a	1.7 (1.7-5.2)^a	6.0 (5.7-7.3)
3	>64	0.5	3-5.5^b	5.4 (3.6-6.3)	5.4 (3.6-6.3)	5.3 (3.0-6.3)	5.2 (4.3-6.2)	4.9 (3.8-5.6)	4.4 (3.6-5.5)^a	5.5 (2.6-6.3)

^a

P ≤ 0.05 (significant reduction) compared with controls.

^b

Pooled studies.