Table 5.
Association Between Baseline Serum TSH and Five-Year Change in Blood Pressure in the Pooled Population
| Power-transformed TSH (PTSH) | Low TSHa | High TSHa | TSH in the reference range | |
|---|---|---|---|---|
| β | ||||
| Systolic blood pressure, mmHg | −2.2 (−6.1; 1.7) | 1.0 (−0.6; 2.5) | −0.2 (−1.7; 1.3) | −0.6 (−1.4; 0.1) |
| Diastolic blood pressure, mmHg | −2.6* (−4.9; −0.2) | 0.7 (−0.4; 1.9) | −0.7 (−1.5; 0.2) | −0.5 (−0.9; 0.1) |
| Pulse pressure, mmHg | 0.80 (−2.2; 3.8) | −0.1 (−1.6; 1.4) | 0.7 (−0.8; 2.3) | −0.2 (−0.7; 0.2) |
| Relative risk | ||||
| Hypertensionb | 1.33 (0.87; 2.04) | 1.13 (0.92; 1.40) | 1.18 (0.99; 1.41) | 1.00 (0.89; 1.11) |
n=10,048; n=8734 for analyses regarding TSH in the reference range. Median regression for continuous outcomes, Poisson regression for dichotomous outcomes; all models adjusted for baseline values of age, sex, body mass index, smoking status, and study. Fractional polynomials were applied to test for a nonlinear relationship between serum TSH levels and the respective outcome. Inverse probability weights were used to account for loss to follow-up.
a
Compared to serum TSH levels within the reference range (0.3–3.0).
b
Defined as diastolic blood pressure ≥90 mmHg, systolic blood pressure ≥140 mmHg, or intake of antihypertensive medication.
*
p<0.05.