Table 2.
Genes up-regulated in HDF grown on tropoelastin-coated surfaces relative to a control surface as identified by microarray analysis
| Accession number | Gene | Gene name | Fold change | Signal intensity on control | Signal intensity on tropoelastin |
|---|---|---|---|---|---|
| NM_002426 | MMP-12 | Matrix metalloproteinase 12 (metalloelastase) | 9.0 | 60.6 ± 9.0 | 545.2 ± 82.0 |
| NM_002575 | PAI-2 | Plasminogen activator inhibitor 2 | 7.5 | 62.4 ± 4.5 | 469.6 ± 80.3 |
| NM_000584 | CXCL8 | Interleukin-8 (IL-8) | 5.0 | 45.6 ± 6.1 | 227.8 ± 4.4 |
| NM_002994 | CXCL5 | CXC chemokine ligand 5 | 4.5 | 107.6 ± 7.9 | 482.2 ± 5.6 |
| NM_001511 | CXCL1 | CXC chemokine ligand 1 | 3.4 | 121.7 ± 23.2 | 415.2 ± 9.3 |
| NM_006528 | TFPI2 | Tissue factor plasminogen inactivator 2 | 3.0 | 110.9 ± 9.8 | 334.2 ± 11.6 |
| NM_001024465 | SOD2 | Superoxide dismutase 2 | 2.7 | 164.8 ± 6.3 | 438.0 ± 6.4 |
| NM_005733 | KIF20A | Kinesin family member 20A | 2.4 | 310.2 ± 14.5 | 734.8 ± 66.1 |
| NM_000710 | BDKRB1 | Bradykinin receptor B1 | 2.1 | 189.6 ± 18.1 | 403.4 ± 42.4 |
| NM_018136 | ASPM | Abnormal spindle homolog | 2.1 | 273.5 ± 26.9 | 581.6 ± 50.0 |
| NM_005328 | HAS2 | Hyaluronan synthase 2 | 2.1 | 980.0 ± 26.5 | 2049.5 ± 157.6 |