Table 1.

Intramural spreading distance after neoadjuvant therapy

Ref.	No. of patients	Neoadjuvant therapy regimen		Intramural spreading distance
		Radiotherapy (Gy)	Chemotherapy	0-5 mm	6-10 mm	>10 mm
Chmielik et al[32]	106	5 × 5	None	93	9	4
Chmielik et al[32]	86	50.4	5-Fu + LV	78	8	0
Mezhir et al[37]	20	50.4	5-Fu + LV	12	7	1
Guillem et al[36]	109	50.4	5-Fu + LV	108	1	0

5-Fu: 5-fluorouracil; LV: Leucovorin.