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(A) A schematic drawing of the biolistic set up system, modified from Shefi at el. 2006 [6]. (B) A representation of the preparation route of the PSi carriers: (i) Si substrate is subjected to electrochemical etching for 225 s at 15 mA/cm2, followed by (ii) lift-off of the porous layer from the bulk Si and ultrasonication, to produce particles ranging in size from 2 to 18 μm, and (iii) the anticancer drug, MTX, is loaded into the particles by physically adsorption.
