Table 5. MiRNA predictions for target genes associated with significant coronary disease using TARGETSCAN.

Individual miRNAs target genes identified as significantly different between patients with and without significant coronary disease were selecting using the context score, a sum of; site-type contribution, 3’ pairing contribution, local AU contribution, and position contribution. The lowest scores show highest predictions.

Target gene	Gene name/miRNA Name	Total Context Score
hsa-miR-494*
SOCS6	Suppressor of cytokine signaling 6	-1.06
HMGCS1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	-0.88
COL6A6	Collagen type VI alpha 6	-0.64
BCAP29	B-cell receptor-associated protein 29	-0.53
SCARB2	Scavenger receptor class B, member 2	-0.52
IGF1R	Insulin-like growth factor 1 receptor	-0.31
F11R	F11 receptor	-0.41
hsa-miR-490-3p*
LEP	Leptin	-0.32
IL1RAP	Interleukin 1 receptor accessory protein	-0.31
CD63	CD63 molecule	-0.29
TGFBR1	Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)	-0.21
ADIPOR2	Adiponectin receptor 2	-0.2
MEF2D	Myocyte enhancer factor 2D	0
hsa-miR-769-3p*
FAM130A1	Family with sequence similarity 130, member A1	-0.4
SHPK	Sedoheptulokinase	-0.39
KCNA5	Potassium voltage-gated channel, shaker-related subfamily, member 5	-0.35
MARCKS	Myristoylated alanine-rich protein kinase C substrate	-0.25
PBRM1	Polybromo 1	-0.24
ISOC2	Isochorismatase domain containing 2	-0.23
MYCL1	V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	-0.23
KPNA6	Karyopherin alpha 6 (importin alpha 7)	-0.2
KDSR	3-ketodihydrosphingosine reductase	-0.17
COLEC12	Collectin sub-family member 12	-0.15
TSPAN1	Tetraspanin 1	-0.15
PIM2	Pim-2 oncogene	-0.11
KIAA1128	Family with sequence similarity 190, member B (FAM190B)	-0.07