Table 2.
Least Squares Means (SE) for Cognitive, Mood, and Quality of Life Measures
| Outcome | Baseline N=34 |
12 Weeks N=23 |
24 Weeks N=19 |
30 Weeks N=19 |
p-value* |
|---|---|---|---|---|---|
| Cognitive Functioning | |||||
| Mini-Mental State Exam | 28.0 (0.50) | 27.7 (0.56) | 27.9 (0.59) | 27.9 (0.59) | 0.791 |
| Digit Span Test, total | 12.5 (0.60) | 12.3 (0.66) | 12.7 (0.69) | --- | 0.758 |
| FAS test | 27.1 (1.83) | 27.0 (1.90) | 28.7 (1.93) | --- | 0.131 |
| Trail Making Test-A, sec. | 62.3 (6.47) | 59.9 (8.08) | 52.5 (5.34) | 47.1 (4.32) | 0.002 |
| Trail Making Test-B, sec. | 157.8 (11.3) | 142.4 (12.0) | 147.9 (12.2) | 129.2 (12.9) | 0.007 |
| California Verbal Learning Test - II | |||||
| Short-delay free recall | 7.99 (0.61) | 8.55 (0.68) | 9.40 (0.71) | 9.35 (0.71) | 0.023 |
| Long-delay free recall | 8.76 (0.63) | 9.18 (0.69) | 9.50 (0.73) | 9.35 (0.73) | 0.237 |
| Modified Rey-Osterrieth Figure | |||||
| Immediate recall | 14.2 (0.90) | 16.4 (0.99) | 17.5 (1.04) | --- | <0.001 |
| Delayed recall | 13.7 (0.89) | 16.2 (1.00) | 17.0 (1.06) | --- | 0.002 |
| Mood | |||||
| Profile of mood states, total negative scales | 53.3 (5.18) | 43.3 (5.66) | 39.0 (5.88) | 41.7 (5.88) | 0.005 |
| Profile of mood states, total negative - vigor | 40.5 (5.76) | 29.8 (6.25) | 24.1 (6.47) | 26.8 (6.47) | 0.002 |
| Health-related Quality of Life | |||||
| Brain Specific Concerns | 48.4 (1.60) | 52.2 (1.76) | 55.0 (1.93) | 54.6 (2.01) | 0.001 |
| Physical Functioning | 21.5 (0.63) | 22.3 (0.73) | 24.1 (0.79) | 22.7 (0.79) | 0.003 |
| Emotional Functioning | 17.6 (0.79) | 18.6 (0.85) | 19.8 (0.91) | 19.3 (0.96) | 0.011 |
| Social Functioning | 22.6 (0.97) | 21.6 (1.07) | 21.4 (1.17) | 22.2 (1.22) | 0.306 |
| Functional | 18.9 (0.94) | 18.3 (1.00) | 19.1 (1.08) | 18.9 (1.13) | 0.842 |
*
contrast between baseline and 24 weeks