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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2013 Mar 3;71(5):1231–1240. doi: 10.1007/s00280-013-2117-x

Table 1.

Population parameter estimates from the PD model

Parameter (units) Parameter description Estimate (% RSE)
TV(0) (mm3) Baseline tumor volume 115 (7.1)
kg (mm3/h−) Net tumor growth rate constant 0.37 (10.6)
IC50E (ng/mL) Inhibition constant everolimus 153 (67.3)
IC50S (ng/mL) Inhibition constant sorafenib 734 (35.7)
Ψ Interaction term 0.321 (102)
IIV TV(0) Inter-individual variability in baseline tumor volume 68.5 (18.7)
IIV kg Inter-individual variability in Net tumor growth rate constant 87.8 (17.4)
Res Err 1 (%) Proportional residual error 18.0 (13.8)
Res Err 2 (mm3) Additive residual error 12 (51.1)