Table 1.
Peak Inspiratory Pressure (cm H2O) |
Respiratory Compliance (μl/cm H2O) |
|||
---|---|---|---|---|
1 h HVT | End of HVT | 1 h HVT | End of HVT | |
Inhalation | ||||
0 ppm H2S | 35 ± 0.3 | 43 ± 0.1* | 38 ± 1.1 | 22 ± 1.6 |
1 ppm H2S | 34 ± 0.4 | 42 ± 0.7* | 40 ± 1.3 | 20 ± 2.2* |
5 ppm H2S | 35 ± 0.6 | 42 ± 0.1* | 40 ± 0.6 | 18 ± 1.3* |
60 ppm H2S | 33 ± 0.5 | 42 ± 0.2* | 39 ± 0.9 | 18 ± 0.7* |
Intravascular infusion | ||||
Vehicle | 34 ± 0.2 | 43 ± 0.3* | 40 ± 0.4 | 24 ± 1.4* |
Na2S, 0.55 mg/kg | 35 ± 0.2 | 39 ± 0.6† | 39 ± 0.6 | 34 ± 2.3† |
Respiratory mechanics were measured in mice subjected to high tidal volume (HVT) ventilation. Values represent mean ± SEM after 60 min (1 h HVT) and at the end of HVT ventilation (maximum 240 min).
P < 0.05 vs. 1 h HVT.
P < 0.05 vs. vehicle.
H2S = hydrogen sulfide; Na2S = sodium sulfide.